RAF Typhoon FGR4s have operated alongside French aircraft in a joint strike on an hidden munitions depot in Syrian territory operated by the IS group, according to the British defence ministry.
The location, pinpointed through reconnaissance, was thought to be storing arms and explosives, the release indicated, and was situated in mountains just north of Palmyra in Syria's central region.
"Our aircraft utilized precision-guided Paveway IV munitions to hit a several approach shafts down to the facility... preliminary assessments are that the target was engaged successfully," the ministry announced.
There was no evidence of any civilian casualties in the strike conducted Saturday night and every plane involved made a safe return, the MoD added.
The British jets were supported by a Voyager aerial refuelling aircraft.
IS - also known as Daesh - established extremist governance over significant areas in Iraq and Syria prior to its 2019 collapse.
"This strike shows the UK's leading role, and resolve to operate in unison with allied nations, to eradicate any resurgence of the terrorist group and their violent and radical beliefs in the Middle East," the British Defence Secretary John Healey remarked.
UK warplanes have conducted surveillance missions over Syria to "forestall any efforts to regroup" of the group following its military defeat at the climactic battle in Baghuz in 2019, the MoD reported.
"I extend gratitude to all the members of our armed forces involved in this strike for their expertise and their valour," he added. "They were part of thousands of UK service members stationed over the festive period. This mission, to remove militants who pose a risk to our safety, demonstrates how British military are ready to step up, continuously, ensuring Britain's security at home and powerful internationally."
In December, the American forces conducted what it described as a "major assault" on Daesh sites in the country, after an assault resulted in the deaths of two US servicemembers and a civilian linguist in Palmyra.
The United Nations reports Islamic State still has between 5,000 and 7,000 militants in Syria and Iraq.
